Wolff-Chaikoff effect

Wolff-Chaikoff effect
the inhibition of thyroid hormone production by administration of large doses of iodide. This occurs at a critical dosage level below which the addition of iodide to an iodine-deficient individual results in increased production of thyroid hormone. The effect is transient in individuals with normal thyroids but may persist in thyroiditis; it can be utilized medically to induce a hypothyroid state, for example in patients with thyroid crisis (see Lugol's iodine) [Wolff (1898–1972), US cardiologist; I. L. Chaikoff (20th century), US physiologist]

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  • Wolff-Chaikoff effect — is used to describe hypothyroidism caused by ingestion of a large amount of iodine. [GeorgiaPhysiology|5/5ch5/s5ch5 6] It is an autoregulatory phenomenon which inhibits formation of thyroid hormones inside of the thyroid follicle. This becomes… …   Wikipedia

  • Wolff-Chaikoff effect — the inhibition of thyroid hormone production by administration of large doses of iodide. This occurs at a critical dosage level below which the addition of iodide to an iodine deficient individual results in increased production of thyroid… …   Medical dictionary

  • effect — The result or consequence of an action. [L. efficio, pp. effectus, to accomplish, fr. facio, to do] abscopal e. a reaction produced following irradiation but occurring outside the zone of actual radiation absorption. additive e. an e. wherein two …   Medical dictionary

  • Wolff — Julius, German anatomist, 1836–1902. See W. law. Kaspar F., German embryologist in Russia, 1733–1794. See wolffian body, wolffian cyst, wolffian duct, wolffian rest, wolffian ridge, wolffian tubules, under tubule. Louis, U.S. cardiologist,… …   Medical dictionary

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  • Armour Thyroid — (thyroid tablets, USP) is a product derived from porcine thyroid glands. Each grain contains 38 micrograms of levothyroxine (T4) and 9 micrograms of liothyronine (t3). Inactive ingredients are calcium stearate, dextrose, microcrystalline… …   Wikipedia

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  • Hypothyroidism — Infobox Disease Name = Hypothyroidism Caption = Thyroxine (T4) normally produced in 20:1 ratio to triiodothyronine (T3) DiseasesDB = 6558 ICD10 = ICD10|E|03|9|e|00 ICD9 = ICD9|244.9 ICDO = OMIM = MedlinePlus = eMedicineSubj = med eMedicineTopic …   Wikipedia

  • Jodbasedow — Jod Basedow effect is used to describe hyperthyroidism following administration of iodine or iodide, either as a dietary supplement or as contrast medium. This phenomenon is an iodine induced hyperthyroidism, typically presenting in a patient… …   Wikipedia

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